Antigen induces leucopenia in non-immunised guinea-pigs injected with platelets from actively sensitized animals
نویسندگان
چکیده
منابع مشابه
the role of nitric oxide in airway responsiveness in diabetic-antigen sensitized guinea pigs in vitro
clinical asthma and airway responsiveness appear to be less severe when diabetes is superimposed. the aim of the present study was to determine the possible role of nitric oxide (no) in the airway reactivity under diabetic and diabetic-allergic conditions. twenty-five male guinea-pigs were divided into five groups of five each as follows: diabetic, antigen sensitized, diabetic- antigen sensitiz...
متن کاملEffect of KW-4679, an orally active anti-allergic drug, on antigen-induced airway hyperresponsiveness in actively sensitized guinea pigs.
We investigated the effect of KW-4679 ((Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b, e]oxepin-2- acetic acid monohydrochloride), an orally active anti-allergic drug, on antigen-induced airway hyperresponsiveness using two different indicators, pulmonary resistance (RL) and dynamic lung compliance (Cdyn), in actively sensitized guinea pigs. Oral administration of KW-4679 (0.1 and 1...
متن کاملComparison of cough reflex sensitivity after an inhaled antigen challenge between actively and passively sensitized guinea pigs
BACKGROUND Late asthmatic response is observed following antigen challenge in actively, but not passively, sensitized guinea pigs. Although cough reflex sensitivity is increased after antigen challenge in actively sensitized guinea pigs, it is unknown whether the antigen-induced increase in cough reflex sensitivity develops in passively sensitized animals. The aim of this study was to compare t...
متن کاملSome liver function indicators in guinea pigs injected with cyanide
To determine the lethal effect of cyanide poisoning on the liver cells using ALP, AST, ALT and Bilirubin (Total and Conjugated) as test indicators, eighteen (18) male guinea pigs, age matched were used for this study. This included 12 guinea pigs which served as test groups and injected with different concentrations of potassium cyanide saline solution while 6 guinea pigs without cyanide inject...
متن کاملInhibitory effects of OKY-046 on spasmogen-induced bronchoconstrictions in sensitized and non-sensitized guinea pigs.
We examined the effect of thromboxane A2 (TXA2) synthetase inhibitor, OKY-046, on bronchoconstriction induced by antigen and various spasmogenic mediators in guinea pigs in vivo. Further, inhibitory activities of OKY-046 on contractions of isolated tracheae and lung parenchymal strips induced by various contractile agents were also investigated in vitro. OKY-046, but not indomethacin, significa...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1990
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1990.tb12074.x